[1]朱统寅,孙军辉,陈新华,等.CT导引纳米刀消融猪肝脏可行性实验研究[J].介入放射学杂志,2016,(04):337-340.
 ZHU Tong- yin,SUN Jun- hui,CHEN Xin- hua,et al.CT- guided NanoKnife ablation of experimental pig liver: a feasibility study[J].journal interventional radiology,2016,(04):337-340.
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CT导引纳米刀消融猪肝脏可行性实验研究 ()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2016年04期
页码:
337-340
栏目:
实验研究
出版日期:
2016-04-25

文章信息/Info

Title:
CT- guided NanoKnife ablation of experimental pig liver: a feasibility study
作者:
朱统寅 孙军辉 陈新华 彭志毅 任志刚 聂春晖 周坦洋 张雄信王伟林 郑树森
Author(s):
ZHU Tong- yin SUN Jun- hui CHEN Xin- hua PENG Zhi- yi REN Zhi- gang NIE Chun- hui ZHOU Tan- yang ZHANG Xiong- xin WANG Wei- lin ZHENG Shu- sen
Interventional Diagnosis and Treatment Center of Hepatobiliary and Pancreatic Diseases, Affiliated First Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang Province 310003, China
关键词:
【关键词】 消融 纳米刀 计算机断层扫描 动物实验
文献标志码:
A
摘要:
【摘要】 目的 评估CT导引经皮纳米刀消融猪肝组织的可行性及安全性。方法 10头成年巴马小型猪随机分为实验组(n=7)和对照组(n=3),全身麻醉下将NanoKnife纳米刀双针电极经CT导引穿刺至肝脏肝门区及肝脏近胆囊处,依标准参数进行消融。术后2 h、2 d、7 d、14 d取材作生化、病理学检查。 结果 所有实验过程均顺利,未出现出血、感染、气胸、死亡等严重并发症,所有实验猪均存活至实验终点。生化指标检测提示肝功能及心肌酶谱指标出现一过性升高,消融后14 d逐渐恢复正常;病理学检查提示消融后2 d内消融区细胞完全死亡,血管内皮轻度损伤,2 d后产生再次内皮化,14 d后平滑肌细胞重新长入。结论 纳米刀消融邻近肝门大血管、胆管、胆囊的猪肝脏组织是安全可行的,为纳米刀技术临床应用提供了大动物实验依据。

参考文献/References:

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备注/Memo

备注/Memo:
(收稿日期:2015-11-29)

(本文编辑:边 佶)
更新日期/Last Update: 2016-04-21