[1]张   磊,陆骊工,李   勇,等.门静脉支架联合肝动脉化疗栓塞治疗肝癌伴门静脉癌栓的临床研究[J].介入放射学杂志,2011,(12):968-973.
 ZHANG Lei,LU Li-gong,LI Yong,et al.Portal vein stent placement combined with TACE for the treatment of hepatocellular carcinoma associated with tumor thrombus in portal vein[J].journal interventional radiology,2011,(12):968-973.
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门静脉支架联合肝动脉化疗栓塞治疗肝癌伴门静脉癌栓的临床研究()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2011年12期
页码:
968-973
栏目:
肿瘤介入
出版日期:
2011-12-30

文章信息/Info

Title:
Portal vein stent placement combined with TACE for the treatment of hepatocellular carcinoma associated with tumor thrombus in portal vein
作者:
 张   磊   陆骊工   李   勇   邵培坚   胡宝山   魏照光   何   旭   禹娴怡   罗小宁
510080 广东省人民医院肿瘤中心介入治疗科,广东省医学科学院
Author(s):
ZHANG Lei LU Li-gong LI Yong SHAO Pei-jian HU Bao-shan WEI Zhao-guang HE Xu YU Xian-yi LUO Xiao-ning.
Department of Interventional Radiology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China
关键词:
 【关键词】 肝癌 门静脉癌栓 经皮经肝门静脉内支架植入术 经导管动脉化疗栓塞
文献标志码:
A
摘要:
 【摘要】 目的 探讨经皮肝门静脉内支架植入术(PTPVS)联合肝动脉化疗栓塞(TACE)治疗肝癌伴门静脉癌栓的临床疗效及安全性,并探索影响疗效的因素。方法 2009年1月- 2010年10月在已临床确诊为肝癌伴门静脉癌栓患者中,按要求筛选病例62例,采用对照、非随机方法分为治疗组和对照组,对照组30例单接受TACE治疗;治疗组32例先接受PTPVS再行TACE治疗,其中2例病例放置门静脉支架未成功。评价指标为总生存时间和安全性。随访患者生存时间,并记录PTPVS术后并发症。用 KaplanMeier 生存分析法分析患者生存时间,两组间生存时间比较用 Logrank法检验;用 Cox 比例风险回归模型探讨影响患者临床预后的因素。结果   治疗组中位总生存期为6.5个月,对照组中位总生存期为4.5个月(治疗组风险比为0.570,95%CI为0.328 ~ 0.992,P = 0.037),两组间差异有统计学意义(P <0.05)。治疗组30例患者在3、6、12和18个月积累生存率分别为70%、56.7%、10%、3.3%。治疗组在术后1周内未出现手术相关并发症,远期出现的并发症有肝性脑病(2例,6.6%)、上消化道出血(呕血或黑便,3例,10%)、肝肾综合征(1例,3.3%)。结论   在肝癌合并门静脉一级分支或(和)门静脉主干不完全闭塞癌栓患者中,PTPVS联合TACE治疗组中位生存期比单独TACE治疗组延长约2个月。治疗方案的安全性较好。 

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(收稿日期:2011-04-28)
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