[1]郭建海,杨仁杰.血清nm23-H1水平对肝细胞肝癌TACE治疗预后的影响[J].介入放射学杂志,2010,(06):463.
 GUO Jianhai,Yang Renjie.Impact of serum nm23-H1level on the prognosis of hepatocellular carcinoma after transcatheter arterial chemoembolization treatment[J].journal interventional radiology,2010,(06):463.
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血清nm23-H1水平对肝细胞肝癌TACE治疗预后的影响()

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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
期数:
2010年06期
页码:
463
栏目:
肿瘤介入
出版日期:
2010-06-15

文章信息/Info

Title:
Impact of serum nm23-H1level on the prognosis of hepatocellular carcinoma after transcatheter arterial chemoembolization treatment
作者:
郭建海杨仁杰
100142北京北京大学临床肿瘤学院、北京肿瘤医院暨北京市肿瘤防治研究所介入治疗科,恶性肿瘤发病机制及转化研究教育部重点实验室
Author(s):
GUO Jian-haiYang Ren-jie
Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education),Department of Interventional Therapy,School of Oncology,Peking University,Beijing Cancer Hospital&Institute,Beijing100142,China
关键词:
肝细胞肝癌TACEnm23-H1基因预后酶联免疫吸附试验
分类号:
R735.7
文献标志码:
A
摘要:
目的探讨肝细胞肝癌患者血清nm23-H1基因水平及其对TACE治疗预后的影响。方法收集60例行TACE治疗的肝细胞肝癌患者血清,采用ELISA检测血清nm23-H1水平,并与12例正常对照组进行比较。回顾性分析所有患者的临床病理资料,对患者血清nm23-H1水平与临床资料进行相关性分析,用Kaplan-Meier生存曲线分析患者生存率,并用log等级检验比较。多因素分析方法评估血清nm23-H1水平及相关因素对预后的意义。结果肝细胞肝癌患者血清nm23-H1平均水平为(126.4±51.3)ng /ml ,明显低于正常对照组的(228.3±38.9)ng /ml (P<0.01)。患者血清nm23-H1水平与白蛋白水平呈负相关(r=-0.256,P=0.048),而与患者年龄及血清AFP、ALT、AST、GGT、胆红素水平均无相关性。随访1周~83个月,中位随访时间为17.5个月。单因素分析显示肝外转移、门静脉瘤栓、动静脉瘘和血清AFP升高是预后不良的因素。多因素COX模型分析显示血清nm23-H1水平是影响生存的因素之一。结论血清nm23-H1水平有可能作为肝细胞肝癌患者TACE治疗疗效观察及预后判断的有用指标。

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备注/Memo

备注/Memo:
收稿日期:2010-01-26
基金项目:国家传染病防治科技重大专项资助(项目编号:2008ZX10002-26)
更新日期/Last Update: 2010-06-15