[1]刘小希,邹 文,孟刘坤,等.急性冠状动脉综合征患者PCI术后受体相互作用蛋白激酶1表达及其与支架内再狭窄的关系 [J].介入放射学杂志,2021,30(05):438-442.
 LIU Xiaoxi,ZOU Wen,MENG Liukun,et al.The expression level of receptor-interacting protein kinase 1 in patients with acute coronary syndrome after PCI and its relationship with in-stent restenosis[J].journal interventional radiology,2021,30(05):438-442.
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急性冠状动脉综合征患者PCI术后受体相互作用蛋白激酶1表达及其与支架内再狭窄的关系
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《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
30
期数:
2021年05
页码:
438-442
栏目:
心脏介入
出版日期:
2021-05-25

文章信息/Info

Title:
The expression level of receptor-interacting protein kinase 1 in patients with acute coronary syndrome after PCI and its relationship with in-stent restenosis
作者:
刘小希 邹 文 孟刘坤 宋 民
Author(s):
LIU Xiaoxi ZOU Wen MENG Liukun SONG Min.
Center of Adult Cardiac Surgery, Chinese Academy of Medical Sciences, Peking Union Medical College, National Cardiovascular Center, Fuwai Hospital, Beijing 100037, China
关键词:
【关键词】 急性冠状动脉综合征经皮冠状动脉介入治疗受体相互作用蛋白激酶1支架内再狭窄
文献标志码:
A
摘要:
【摘要】 目的 探讨急性冠状动脉综合征(ACS)患者经皮冠状动脉介入治疗(PCI)后外周血单个核细胞中受体相互作用蛋白激酶(RIPK)1表达及其与支架内再狭窄(ISR)的关系。方法 选择2017年4月至2019年6月在北京阜外医院接受PCI治疗的188例ACS患者作为研究对象。根据PCI术后1年是否发生ISR,分为ISR组(n=51)和非ISR组(n=137)。采用Ficoll密度梯度离心法自外周血中分离单个核细胞,蛋白质免疫印迹法检测单个核细胞中RIPK1表达水平。结果 PCI术后,两组RIPK1表达水平均降低,非ISR组低于ISR组,差异有统计学意义(P<0.05)。非ISR组PCI术前、术后RIPK1降低程度(△RIPK1)高于ISR组,差异均有统计学意义(P<0.05)。PCI术后RIPK1诊断ISR的受试者工作特征曲线下面积、灵敏度、特异度分别为0.868、78.43%、84.67%,其诊断效能高于术前RIPK1和△RIPK1,差异均有显著统计学意义(P<0.001)。多因素logistic回归分析结果显示空腹血糖(FBG)、血管病变支数、术后RIPK1和血管病变长度,均为ACS患者PCI术后1年内ISR的独立危险因素(P<0.05)。限制性立方样条拟合logistic回归分析表明,RIPK1与ISR呈线性关系。结论 RIPK1与ACS患者PCI后1年内ISR有关,其高表达水平提示PCI术后1年内发生ISR风险高。

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备注/Memo

备注/Memo:
(收稿日期:2020-09-29)
(本文编辑:边 佶)
更新日期/Last Update: 2021-05-20