[1]于 翔,谢 坪,成思航,等.经颈静脉肝内门体分流术前外周血炎症指标对术后肝性脑病的预测价值 [J].介入放射学杂志,2021,30(09):937-940.
 YU Xiang,XIE Ping,CHENG Sihang,et al.The clinical value of preoperative peripheral blood inflammatory markers in predicting the occurrence of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt[J].journal interventional radiology,2021,30(09):937-940.
点击复制

经颈静脉肝内门体分流术前外周血炎症指标对术后肝性脑病的预测价值
()

PDF下载中关闭

分享到:

《介入放射学杂志》[ISSN:1008-794X/CN:31-1796/R]

卷:
30
期数:
2021年09
页码:
937-940
栏目:
临床研究
出版日期:
2021-09-25

文章信息/Info

Title:
The clinical value of preoperative peripheral blood inflammatory markers in predicting the occurrence of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt
作者:
于 翔 谢 坪 成思航 曹 磊 顾 露 朱 玥
Author(s):
YU Xiang XIE Ping CHENG Sihang CAO Lei GU Lu ZHU Yue.
Department of Radiology, Sichuan Provincial People’s Hospital, Sichuan Provincial Academy of Medical Sciences, Chengdu, Sichuan Province 610041, China
关键词:
【关键词】 经颈静脉肝内门体分流术 肝性脑病 炎性反应 评分系统
文献标志码:
A
摘要:
【摘要】 目的 探讨基于全身炎性反应相关血液指标评分系统预测经颈静脉肝内门体分流术(TIPS)后肝性脑病(HE)的价值。方法 回顾性分析2015年2月至2019年12月在四川省人民医院接受TIPS治疗的106例肝硬化患者临床资料。将TIPS术前患者超敏C反应蛋白(hsCRP)、中性粒细胞/淋巴细胞比值(NLR)、血小板/淋巴细胞比值(PLR)、全身免疫- 炎性指数(SII)、改良Glasgow预后评分(mGPS)纳入单因素分析,获取有统计学意义的变量及临床认为与HE发生密切相关的变量后,进行二元logistic回归多因素分析。结果 多因素分析结果显示,hsCRP(P=0.025)、门静脉压力梯度下降百分比(PPG%)(P=0.022)与TIPS术后HE密切相关。NLR、PLR、SII、mGPS与TIPS术后HE均无显著相关性(P>0.05)。联合hsCRP与PPG%构建的预测模型曲线下面积(AUC)为0.723。 结论 除PPG%外,hsCRP是TIPS术后HE的独立危险因素。

参考文献/References:

[1] Rossle M. TIPS: 25 years later[J]. J Hepatol, 2013, 59:1081-1093.
[2] Riggio O, Nardelli S, Moscucci F, et al. Hepatic encephalopathy after transjugular intrahepatic portosystemic shunt[J]. Clin Liver Dis, 2012, 16:133-146.
[3] 孙旻煌,李迎春,李松蔚,等. Viatorr支架在TIPS治疗中的应用[J]. 介入放射学杂志, 2019, 28:166-169.
[4] 马鹍鹏,梁松年,钟红珊,等. Viatorr支架行TIPS术治疗门静脉高压性静脉曲张消化道出血效果评估[J]. 介入放射学杂志, 2020, 29:380-384.
[5] Labenz C, Toenges G, Huber Y, et al. Raised serum interleukin- 6 identifies patients with liver cirrhosis at high risk for overt hepatic encephalopathy[J]. Aliment Pharmacol Ther, 2019, 50: 1112-1119.
[6] Nardelli S, Gioia S, Pasquale C, et al. Cognitive impairment predicts the occurrence of hepatic encephalopathy after transjugular intrahepatic portosystemic shunt[J]. Am J Gastroenterol, 2016, 111: 523-528.
[7] Trebicka J. Emergency TIPS in a Child- Pugh B patient: when does the window of opportunity open and close?[J]. J Hepatol, 2017, 66: 442- 450.
[8] Kang DJ, Betrapally NS, Ghosh SA, et al. Gut microbiota drive the development of neuroinflammatory response in cirrhosis in mice[J]. Hepatology, 2016, 64: 1232-1248.
[9] 郑 晖,杨维竹,黄 宁,等. 不同直径覆膜支架行经颈静脉肝内门体分流术治疗食管胃底静脉曲张破裂出血[J]. 介入放射学杂志, 2018, 27:167-171.
[10] Siegerstetter V, Rossle M. The role of TIPS for the treatment of portal hypertension: effects and efficacy[J]. Acta Gastroenterol Belg, 1997, 60: 233-237.
[11] 陆伦根. 肝性脑病[J]. 中华消化杂志, 2017, 37:508-512.
[12] Rossle M, Siegerstetter V, Olschewski M, et al. How much reduction in portal pressure is necessary to prevent variceal rebleeding? A longitudinal study in 225 patients with transjugular intrahepatic portosystemic shunts[J]. Am J Gastroenterol, 2001, 96: 3379-3383.

相似文献/References:

[1]郭添胜,姜在波,黄明声,等.原发性肝癌合并糖尿病介入治疗的围手术期处理[J].介入放射学杂志,2000,(03):182.
[2]王茂强,王志强,王仲朴,等.经颈静脉途径肝内门-腔静脉分流术后肝性脑病的原因及其预防[J].介入放射学杂志,1998,(02):71.
[3]杨建勇,刘子江.经颈静脉肝内门体静脉支撑架分流术[J].介入放射学杂志,1994,(03):165.
[4]张子曙,黄祥龙,沈天真,等.经颈静脉肝内门体分流术[J].介入放射学杂志,1994,(04):239.
[5]Artbur M.Freedman,杨建勇.经颈静脉肝内门体静脉分流术的并发症[J].介入放射学杂志,1994,(04):236.
[6]冯常炜,李振峰,崔广林,等.经颈静脉肝内门-腔分流术治疗肝硬变门脉高压症——附5例报告[J].介入放射学杂志,1995,(04):215.
[7]李晓晖,练贤惠,蔡银科,等.经颈静脉肝内门体静脉分流术后并发症的观察与护理[J].介入放射学杂志,2000,(02):116.
[8]何创业,祁兴顺,帖 君,等.经颈内静脉肝内门体分流术联合封堵器封堵治疗肝硬化门脉高压伴自发性脾、胃-肾分流[J].介入放射学杂志,2013,(10):801.
 HE Chuang? ye,QI Xing? shun,TIE Jun,et al. Transjugular intrahepatic portosystemic shunt combined with Amplatzer plugging device therapy for cirrhotic portal hypertension with spontaneous spleno?蛳 gastric?蛳 renal shunt[J].journal interventional radiology,2013,(09):801.
[9]唐世伟,赵新建,王忠敏,等.TIPS对比EBL治疗肝硬化食管静脉曲张出血Meta分析[J].介入放射学杂志,2016,(09):761.
 TANG Shi- wei,ZHAO Xin- jian,WANG Zhong- min,et al.The treatment of cirrhosis esophageal variceal bleeding: a meta- analysis of TIPS versus EBL[J].journal interventional radiology,2016,(09):761.
[10]彭伦华,王运兵,郭 灿.球囊阻断逆行经静脉闭塞对比经颈静脉肝内门体分流治疗门脉高压胃底静脉曲张出血的Meta分析[J].介入放射学杂志,2016,(10):843.
 PENG Lun- hua,WANG Yun- bing,GUO Can.Balloon- occluded retrograde transvenous obliteration versus TIPS for treatment of gastric fundus varices due to portal hypertension: a meta- analysis[J].journal interventional radiology,2016,(09):843.
[11]陈 杨,刘家成,杨崇图,等.经颈静脉肝内门体分流术后肝性脑病预后因素研究进展[J].介入放射学杂志,2022,31(03):301.
 CHEN Yang,LIU Jiacheng,YANG Chongtu,et al.Research progress in studying the prognostic factors of hepatic encephalopathy occurring after transjugular intrahepatic portosystemic shunt[J].journal interventional radiology,2022,31(09):301.

备注/Memo

备注/Memo:
(收稿日期:2020-12-23)
(本文编辑:边 佶)
更新日期/Last Update: 2021-09-13